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生命科學學院“高端學術論壇”之134

報告題目：How do brain cells communicate with each other and why is it critical to human behavior?

（腦細胞如何相互交流以及為什么它對人類行為至關重要）

報告人：Dr. Stephen Meriney匹茲堡大學神經科學系教授

時間：2018年10月23日(星期二）13：30-14：30

地點：文清樓306室

生命科學學院“高端學術論壇”之135

報告題目：The development of new treatments for neuromuscular disease

（開發神經肌肉疾病的新療法）

報告人：Dr. Stephen Meriney匹茲堡大學神經科學系教授

時間：2018年10月24日（星期三）10：00-11：00

地點：行政東樓后座316會議室

Stephen Meriney簡介

Stephen Meriney博士，匹茲堡大學神經科學系教授。1986年獲得博士學位; 1987-1993年在加州大學洛杉磯分校從事博士后研究；自1993年至今在匹茲堡大學神經科學系歷任助理教授、副教授、終身教授。Meriney博士的主要研究方向為神經元突觸信息傳遞的分子細胞機制，包括離子通道的生物物理研究，神經肌肉突觸的電生理研究，突觸前神經末梢的鈣成像，神經肌肉的新治療方法的開發疾病和MCell計算機模擬神經末梢內的微生理。

代表性論文：

Meriney SD, Gray DB. Pilar G. (1985) Morphine-induced delay of normal cell death in the avian ciliary ganglion. Science 228: 1451-1453.

Pilar G. Nunez R. McLennon I. Meriney SD. (1987) Muscarinic and nicotinic synaptic activation of the developing chicken iris. Journal of Neuroscience 7: 3813-3826.

Meriney SD. Pilar G. (1987) Cholinergic innervation of the smooth muscle cells in the choroid coat of the chick eye and its development. Journal of Neuroscience 7: 3827-3839.

Meriney SD. Pilar G. Ogawa M. Nunez R. (1987) Differential neuronal survival in the avian ciliary ganglion after chronic acetylcholine receptor blockade. Journal of Neuroscience 7: 3840-3849.

Meriney SD. Young SH. Grinnell AD. (1989) Constraints on the interpretation of nonquantal acetylcholine release from the frog neuromuscular junction. Proceedings of the National Academy of Science, U.S.A. 86: 2098-2102.

Meriney SD. Gray DB. Pilar GR. (1994) Somatostatin-induced inhibition of neuronal Ca2+ current modulated by cGMP-dependent protein kinase. Nature 369: 336-339.

Wachman E. Poage RE. Stiles JR. Farkas D. Meriney SD. (2004) Spatial distribution of calcium entry evoked by single action potentials within the presynaptic active zone. Journal of Neuroscience 24: 2877-2885.

Keith RK. Poage RE. Yokoyama CT. Catterall WA. Meriney SD. (2007) Bidirectional modulation of transmitter release by calcium channel/syntaxin interactions in vivo. Journal of Neuroscience 27: 265-269.

Luo F. Dittrich M. Stiles JR. Meriney SD. (2011) Single pixel optical fluctuation analysis of calcium channel function in active zones of motor nerve terminals. Journal of Neuroscience 31: 11268-11281.

Tarr TB. Dittrich M. Meriney SD. (2013) Are Unreliable Release Mechanisms Conserved from NMJ to CNS? Trends in Neuroscience 36: 14-22.

Tarr TB. Malick W. Liang M. Valdomir G. Frasso M. Lacomis D. Reddel SW. Garcia-Ocano A. Wipf P. Meriney SD. (2013) Evaluation of a novel calcium channel agonist for therapeutic potential in Lambert-Eaton Myasthenic Syndrome. Journal of Neuroscience 33: 10559-10567.

Luo F. Dittrich M. Cho S. Stiles JR. Meriney SD. (2015) Transmitter release is evoked with low probability predominately by calcium flux through single channel openings at the frog neuromuscular junction. Journal of Neurophysiology 113: 2480-2489.

Wu M. White HV. Boehm B. Meriney CJ. Kerrigan K. Frasso M. Liang M. Gotway EM. Wilcox M. Johnson JW. Wipf P. Meriney SD. (2018) New Cav2 calcium channel gating modifiers with agonist activity and therapeutic potential to treat neuromuscular disease. Neuropharmacology 131: 176-189.

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